USP15-SYT1 Fusion FISH Probe
The USP15-SYT1 Fusion FISH Probe is used to confirm a fusion of the USP15 and SYT1 genes. The fusion of the USP15 and SYT1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP15-SYT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-RERE | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-REOR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-REGO | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-REGR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-REAQ | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-ORRE | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-OROR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-ORGO | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GORE | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GOOR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GOGO | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GOGR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GRRE | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GROR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GRGO | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GRGR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-AQRE | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-AQOR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-AQGO | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-AQGR | 20 (40 μL) | 200 μL |
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| USP15-SYT1-20-AQAQ | 20 (40 μL) | 200 μL |
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SYT1 Gene Summary
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Gene Name: Synaptotagmin 1
Chromosome: CHR12: 79257772 -79845788
Locus: 12q21.2
USP15 Gene Summary
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Gene Name: Ubiquitin Specific Peptidase 15
Chromosome: CHR12: 62654186 -62799898
Locus: 12q14.1
Gene Diseases
The USP15 SYT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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