USP15-CPSF6 Fusion FISH Probe
The USP15-CPSF6 Fusion FISH Probe is used to confirm a fusion of the USP15 and CPSF6 genes. The fusion of the USP15 and CPSF6 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP15-CPSF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-RERE | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-REOR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-REGO | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-REGR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-REAQ | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-ORRE | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-OROR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-ORGO | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GORE | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GOOR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GOGO | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GOGR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GRRE | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GROR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GRGO | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GRGR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-AQRE | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-AQOR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-AQGO | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-AQGR | 20 (40 μL) | 200 μL |
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| USP15-CPSF6-20-AQAQ | 20 (40 μL) | 200 μL |
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USP15 Gene Summary
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Gene Name: Ubiquitin Specific Peptidase 15
Chromosome: CHR12: 62654186 -62799898
Locus: 12q14.1
CPSF6 Gene Summary
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cleavage And Polyadenylation Specific Factor 6
Chromosome: CHR12: 69633316 -69668138
Locus: 12q15
Gene Diseases
The USP15 CPSF6 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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