USP14-THOC1 Fusion FISH Probe
The USP14-THOC1 Fusion FISH Probe is used to confirm a fusion of the USP14 and THOC1 genes. The fusion of the USP14 and THOC1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP14-THOC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-RERE | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-REOR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-REGO | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-REGR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-REAQ | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-ORRE | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-OROR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-ORGO | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GORE | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GOOR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GOGO | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GOGR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GRRE | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GROR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GRGO | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GRGR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-AQRE | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-AQOR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-AQGO | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-AQGR | 20 (40 μL) | 200 μL |
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| USP14-THOC1-20-AQAQ | 20 (40 μL) | 200 μL |
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USP14 Gene Summary
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Specific Peptidase 14
Chromosome: CHR18: 158482 -213739
Locus: 18p11.32
THOC1 Gene Summary
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
Gene Name: THO Complex 1
Chromosome: CHR18: 214519 -268059
Locus: 18p11.32
Gene Diseases
The USP14 THOC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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