USP10-CDH13 Fusion FISH Probe
The USP10-CDH13 Fusion FISH Probe is used to confirm a fusion of the USP10 and CDH13 genes. The fusion of the USP10 and CDH13 genes has been associated with Lung Squamous Cell Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP10-CDH13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-RERE | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-REOR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-REGO | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-REGR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-REAQ | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-ORRE | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-OROR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-ORGO | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GORE | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GOOR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GOGO | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GOGR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GRRE | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GROR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GRGO | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GRGR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-AQRE | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-AQOR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-AQGO | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-AQGR | 20 (40 μL) | 200 μL |
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| USP10-CDH13-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH13 Gene Summary
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Gene Name: Cadherin 13
Chromosome: CHR16: 82660398 -83830215
Locus: 16q23.3
USP10 Gene Summary
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Name: Ubiquitin Specific Peptidase 10
Chromosome: CHR16: 84733554 -84813527
Locus: 16q24.1
Gene Diseases
The USP10 CDH13 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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