UPK2-SUPT16H Fusion FISH Probe
The UPK2-SUPT16H Fusion FISH Probe is used to confirm a fusion of the UPK2 and SUPT16H genes. The fusion of the UPK2 and SUPT16H genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UPK2-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| UPK2-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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UPK2 Gene Summary
This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Gene Name: Uroplakin 2
Chromosome: CHR11: 118827007 -118829269
Locus: 11q23.3
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The UPK2 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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