UPF3A-CDC16 Fusion FISH Probe
The UPF3A-CDC16 Fusion FISH Probe is used to confirm a fusion of the UPF3A and CDC16 genes. The fusion of the UPF3A and CDC16 genes has been associated with Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, Thyroid Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UPF3A-CDC16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-RERE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-OROR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GORE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GROR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC16 Gene Summary
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Gene Name: Cell Division Cycle 16
Chromosome: CHR13: 115000361 -115038150
Locus: 13q34
UPF3A Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: UPF3A, Regulator Of Nonsense Mediated MRNA Decay
Chromosome: CHR13: 115047058 -115071291
Locus: 13q34
Gene Diseases
The UPF3A CDC16 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Thyroid Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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