UPF1-EIF3M Fusion FISH Probe
The UPF1-EIF3M Fusion FISH Probe is used to confirm a fusion of the UPF1 and EIF3M genes. The fusion of the UPF1 and EIF3M genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UPF1-EIF3M-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-RERE | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-REOR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-REGO | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-REGR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-REAQ | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-ORRE | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-OROR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-ORGO | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-ORAQ | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GORE | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GOOR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GOGO | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GOGR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GOAQ | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GRRE | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GROR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GRGO | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GRGR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-GRAQ | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-AQRE | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-AQOR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-AQGO | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-AQGR | 20 (40 μL) | 200 μL |
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| UPF1-EIF3M-20-AQAQ | 20 (40 μL) | 200 μL |
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UPF1 Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: UPF1, RNA Helicase And ATPase
Chromosome: CHR19: 18942743 -18979039
Locus: 19p13.11
EIF3M Gene Summary
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Gene Name: Eukaryotic Translation Initiation Factor 3 Subunit M
Chromosome: CHR11: 32605390 -32624014
Locus: 11p13
Gene Diseases
The UPF1 EIF3M Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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