UPF1-CRTC1 Fusion FISH Probe
The UPF1-CRTC1 Fusion FISH Probe is used to confirm a fusion of the UPF1 and CRTC1 genes. The fusion of the UPF1 and CRTC1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UPF1-CRTC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-RERE | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-REOR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-REGO | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-REGR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-REAQ | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-ORRE | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-OROR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-ORGO | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GORE | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GOOR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GOGO | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GOGR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GRRE | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GROR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GRGO | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GRGR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-AQRE | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-AQOR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-AQGO | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-AQGR | 20 (40 μL) | 200 μL |
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| UPF1-CRTC1-20-AQAQ | 20 (40 μL) | 200 μL |
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UPF1 Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: UPF1, RNA Helicase And ATPase
Chromosome: CHR19: 18942743 -18979039
Locus: 19p13.11
CRTC1 Gene Summary
The CREB Regulated Transcription Coactivator 1 (CRTC1) gene is located on chr19 :18794424-18893143 at 19p13.11.
Gene Name: CREB Regulated Transcription Coactivator 1
Chromosome: CHR19: 18794424 -18893143
Locus: 19p13.11
Gene Diseases
The UPF1 CRTC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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