UNC45A-IQGAP1 Fusion FISH Probe
The UNC45A-IQGAP1 Fusion FISH Probe is used to confirm a fusion of the UNC45A and IQGAP1 genes. The fusion of the UNC45A and IQGAP1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UNC45A-IQGAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-RERE | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-REOR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-REGO | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-REGR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-OROR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GORE | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GROR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| UNC45A-IQGAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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IQGAP1 Gene Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Gene Name: IQ Motif Containing GTPase Activating Protein 1
Chromosome: CHR15: 90931472 -91045475
Locus: 15q26.1
UNC45A Gene Summary
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
Gene Name: Unc-45 Myosin Chaperone A
Chromosome: CHR15: 91473409 -91497323
Locus: 15q26.1
Gene Diseases
The UNC45A IQGAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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