UNC45A-BLM Fusion FISH Probe
The UNC45A-BLM Fusion FISH Probe is used to confirm a fusion of the UNC45A and BLM genes. The fusion of the UNC45A and BLM genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UNC45A-BLM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-RERE | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-REOR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-REGO | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-REGR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-REAQ | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-ORRE | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-OROR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-ORGO | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-ORAQ | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GORE | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GOOR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GOGO | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GOGR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GOAQ | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GRRE | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GROR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GRGO | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GRGR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-GRAQ | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-AQRE | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-AQOR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-AQGO | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-AQGR | 20 (40 μL) | 200 μL |
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| UNC45A-BLM-20-AQAQ | 20 (40 μL) | 200 μL |
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BLM Gene Summary
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
Gene Name: Bloom Syndrome RecQ Like Helicase
Chromosome: CHR15: 91260578 -91358686
Locus: 15q26.1
UNC45A Gene Summary
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
Gene Name: Unc-45 Myosin Chaperone A
Chromosome: CHR15: 91473409 -91497323
Locus: 15q26.1
Gene Diseases
The UNC45A BLM Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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