UNC13B-UBE2R2 Fusion FISH Probe
The UNC13B-UBE2R2 Fusion FISH Probe is used to confirm a fusion of the UNC13B and UBE2R2 genes. The fusion of the UNC13B and UBE2R2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UNC13B-UBE2R2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-RERE | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-REOR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-REGO | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-REGR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-REAQ | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-ORRE | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-OROR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-ORGO | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-ORAQ | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GORE | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GOOR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GOGO | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GOGR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GOAQ | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GRRE | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GROR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GRGO | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GRGR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-GRAQ | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-AQRE | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-AQOR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-AQGO | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-AQGR | 20 (40 μL) | 200 μL |
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| UNC13B-UBE2R2-20-AQAQ | 20 (40 μL) | 200 μL |
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UNC13B Gene Summary
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Gene Name: Unc-13 Homolog B
Chromosome: CHR9: 35161988 -35405332
Locus: 9p13.3
UBE2R2 Gene Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 R2
Chromosome: CHR9: 33817181 -33920401
Locus: 9p13.3
Gene Diseases
The UNC13B UBE2R2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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