UMPS-KALRN Fusion FISH Probe
The UMPS-KALRN Fusion FISH Probe is used to confirm a fusion of the UMPS and KALRN genes. The fusion of the UMPS and KALRN genes has been associated with Brain Lower Grade Glioma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UMPS-KALRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-RERE | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-REOR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-REGO | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-REGR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-REAQ | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-ORRE | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-OROR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-ORGO | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GORE | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GOOR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GOGO | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GOGR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GRRE | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GROR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GRGO | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GRGR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-AQRE | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-AQOR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-AQGO | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-AQGR | 20 (40 μL) | 200 μL |
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| UMPS-KALRN-20-AQAQ | 20 (40 μL) | 200 μL |
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UMPS Gene Summary
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Name: Uridine Monophosphate Synthetase
Chromosome: CHR3: 124449212 -124468119
Locus: 3q21.2
KALRN Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
Gene Name: Kalirin RhoGEF Kinase
Chromosome: CHR3: 123813557 -124440036
Locus: 3q21.1-q21.2
Gene Diseases
The UMPS KALRN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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