UHRF1-ACTA2 Fusion FISH Probe
The UHRF1-ACTA2 Fusion FISH Probe is used to confirm a fusion of the UHRF1 and ACTA2 genes. The fusion of the UHRF1 and ACTA2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UHRF1-ACTA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-RERE | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-REOR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-REGO | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-REGR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-REAQ | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-ORRE | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-OROR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-ORGO | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GORE | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GOOR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GOGO | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GOGR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GRRE | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GROR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GRGO | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GRGR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-AQRE | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-AQOR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-AQGO | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-AQGR | 20 (40 μL) | 200 μL |
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| UHRF1-ACTA2-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTA2 Gene Summary
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
Gene Name: Actin, Alpha 2, Smooth Muscle, Aorta
Chromosome: CHR10: 90694830 -90751147
Locus: 10q23.31
UHRF1 Gene Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Gene Name: Ubiquitin Like With PHD And Ring Finger Domains 1
Chromosome: CHR19: 4909509 -4962165
Locus: 19p13.3
Gene Diseases
The UHRF1 ACTA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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