UGGT2-COL4A1 Fusion FISH Probe
The UGGT2-COL4A1 Fusion FISH Probe is used to confirm a fusion of the UGGT2 and COL4A1 genes. The fusion of the UGGT2 and COL4A1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UGGT2-COL4A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-RERE | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-REOR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-REGO | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-REGR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-REAQ | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-ORRE | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-OROR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-ORGO | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GORE | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GOOR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GOGO | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GOGR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GRRE | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GROR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GRGO | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GRGR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-AQRE | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-AQOR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-AQGO | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-AQGR | 20 (40 μL) | 200 μL |
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| UGGT2-COL4A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL4A1 Gene Summary
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Collagen Type IV Alpha 1 Chain
Chromosome: CHR13: 110801309 -110959496
Locus: 13q34
UGGT2 Gene Summary
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Gene Name: UDP-glucose Glycoprotein Glucosyltransferase 2
Chromosome: CHR13: 96453835 -96705736
Locus: 13q32.1
Gene Diseases
The UGGT2 COL4A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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