UBR4-PAX7 Fusion FISH Probe
The UBR4-PAX7 Fusion FISH Probe is used to confirm a fusion of the UBR4 and PAX7 genes. The fusion of the UBR4 and PAX7 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBR4-PAX7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-RERE | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-REOR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-REGO | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-REGR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-REAQ | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-ORRE | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-OROR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-ORGO | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GORE | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GOOR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GOGO | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GOGR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GRRE | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GROR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GRGO | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GRGR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-AQRE | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-AQOR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-AQGO | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-AQGR | 20 (40 μL) | 200 μL |
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| UBR4-PAX7-20-AQAQ | 20 (40 μL) | 200 μL |
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PAX7 Gene Summary
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Paired Box 7
Chromosome: CHR1: 18957499 -19075360
Locus: 1p36.13
UBR4 Gene Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Gene Name: Ubiquitin Protein Ligase E3 Component N-recognin 4
Chromosome: CHR1: 19400999 -19536746
Locus: 1p36.13
Gene Diseases
The UBR4 PAX7 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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