UBR1-TGM5 Fusion FISH Probe
The UBR1-TGM5 Fusion FISH Probe is used to confirm a fusion of the UBR1 and TGM5 genes. The fusion of the UBR1 and TGM5 genes has been associated with Lung Squamous Cell Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBR1-TGM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-RERE | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-REOR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-REGO | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-REGR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-REAQ | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-ORRE | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-OROR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-ORGO | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GORE | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GOOR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GOGO | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GOGR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GRRE | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GROR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GRGO | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GRGR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-AQRE | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-AQOR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-AQGO | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-AQGR | 20 (40 μL) | 200 μL |
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| UBR1-TGM5-20-AQAQ | 20 (40 μL) | 200 μL |
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TGM5 Gene Summary
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
Gene Name: Transglutaminase 5
Chromosome: CHR15: 43524792 -43559055
Locus: 15q15.2
UBR1 Gene Summary
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3 Component N-recognin 1
Chromosome: CHR15: 43235097 -43398286
Locus: 15q15.2
Gene Diseases
The UBR1 TGM5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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