UBN1-MGRN1 Fusion FISH Probe
The UBN1-MGRN1 Fusion FISH Probe is used to confirm a fusion of the UBN1 and MGRN1 genes. The fusion of the UBN1 and MGRN1 genes has been associated with Lung Adenocarcinoma, Breast Invasive Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBN1-MGRN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-RERE | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-REOR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-REGO | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-REGR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-OROR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GORE | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GROR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBN1-MGRN1-20-AQAQ | 20 (40 μL) | 200 μL |
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MGRN1 Gene Summary
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Gene Name: Mahogunin Ring Finger 1
Chromosome: CHR16: 4674824 -4740975
Locus: 16p13.3
UBN1 Gene Summary
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Gene Name: Ubinuclein 1
Chromosome: CHR16: 4897911 -4932363
Locus: 16p13.3
Gene Diseases
The UBN1 MGRN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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