UBN1-BLNK Fusion FISH Probe
The UBN1-BLNK Fusion FISH Probe is used to confirm a fusion of the UBN1 and BLNK genes. The fusion of the UBN1 and BLNK genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBN1-BLNK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-RERE | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-REOR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-REGO | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-REGR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-REAQ | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-ORRE | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-OROR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-ORGO | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GORE | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GOOR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GOGO | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GOGR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GRRE | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GROR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GRGO | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GRGR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-AQRE | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-AQOR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-AQGO | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-AQGR | 20 (40 μL) | 200 μL |
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| UBN1-BLNK-20-AQAQ | 20 (40 μL) | 200 μL |
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BLNK Gene Summary
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: B-cell Linker
Chromosome: CHR10: 97951454 -98031333
Locus: 10q24.1
UBN1 Gene Summary
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Gene Name: Ubinuclein 1
Chromosome: CHR16: 4897911 -4932363
Locus: 16p13.3
Gene Diseases
The UBN1 BLNK Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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