UBE4B-MED18 Fusion FISH Probe
The UBE4B-MED18 Fusion FISH Probe is used to confirm a fusion of the UBE4B and MED18 genes. The fusion of the UBE4B and MED18 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE4B-MED18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-RERE | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-REOR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-REGO | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-REGR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-OROR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GORE | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GROR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE4B-MED18-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE4B Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitination Factor E4B
Chromosome: CHR1: 10093040 -10241296
Locus: 1p36.22
MED18 Gene Summary
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Gene Name: Mediator Complex Subunit 18
Chromosome: CHR1: 28655512 -28662478
Locus: 1p35.3
Gene Diseases
The UBE4B MED18 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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