UBE3B-GNS Fusion FISH Probe
The UBE3B-GNS Fusion FISH Probe is used to confirm a fusion of the UBE3B and GNS genes. The fusion of the UBE3B and GNS genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE3B-GNS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-RERE | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-REOR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-REGO | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-REGR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-OROR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GORE | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GROR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE3B-GNS-20-AQAQ | 20 (40 μL) | 200 μL |
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GNS Gene Summary
The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Glucosamine (N-acetyl)-6-sulfatase
Chromosome: CHR12: 65107221 -65153226
Locus: 12q14.3
UBE3B Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ubiquitin Protein Ligase E3B
Chromosome: CHR12: 109915438 -109974507
Locus: 12q24.11
Gene Diseases
The UBE3B GNS Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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