UBE3A-MYO5C Fusion FISH Probe
The UBE3A-MYO5C Fusion FISH Probe is used to confirm a fusion of the UBE3A and MYO5C genes. The fusion of the UBE3A and MYO5C genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE3A-MYO5C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-RERE | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-REOR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-REGO | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-REGR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-OROR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GORE | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GROR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE3A-MYO5C-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE3A Gene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3A
Chromosome: CHR15: 25582395 -25684175
Locus: 15q11.2
MYO5C Gene Summary
The Myosin VC (MYO5C) gene is located on chr15 :52484514-52587995 at 15q21.2.
Gene Name: Myosin VC
Chromosome: CHR15: 52484514 -52587995
Locus: 15q21.2
Gene Diseases
The UBE3A MYO5C Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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