UBE3A-DTWD1 Fusion FISH Probe
The UBE3A-DTWD1 Fusion FISH Probe is used to confirm a fusion of the UBE3A and DTWD1 genes. The fusion of the UBE3A and DTWD1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE3A-DTWD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE3A-DTWD1-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE3A Gene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3A
Chromosome: CHR15: 25582395 -25684175
Locus: 15q11.2
DTWD1 Gene Summary
The DTW Domain Containing 1 (DTWD1) gene is located on chr15 :49913225-49937333 at 15q21.2.
Gene Name: DTW Domain Containing 1
Chromosome: CHR15: 49913225 -49937333
Locus: 15q21.2
Gene Diseases
The UBE3A DTWD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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