UBE2R2-PRSS3 Fusion FISH Probe
The UBE2R2-PRSS3 Fusion FISH Probe is used to confirm a fusion of the UBE2R2 and PRSS3 genes. The fusion of the UBE2R2 and PRSS3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2R2-PRSS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2R2-PRSS3-20-AQAQ | 20 (40 μL) | 200 μL |
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PRSS3 Gene Summary
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Gene Name: Protease, Serine 3
Chromosome: CHR9: 33750463 -33799229
Locus: 9p13.3
UBE2R2 Gene Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 R2
Chromosome: CHR9: 33817181 -33920401
Locus: 9p13.3
Gene Diseases
The UBE2R2 PRSS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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