UBE2R2-NFX1 Fusion FISH Probe
The UBE2R2-NFX1 Fusion FISH Probe is used to confirm a fusion of the UBE2R2 and NFX1 genes. The fusion of the UBE2R2 and NFX1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2R2-NFX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2R2-NFX1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFX1 Gene Summary
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transcription Factor, X-box Binding 1
Chromosome: CHR9: 33290417 -33371155
Locus: 9p13.3
UBE2R2 Gene Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 R2
Chromosome: CHR9: 33817181 -33920401
Locus: 9p13.3
Gene Diseases
The UBE2R2 NFX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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