UBE2R2-ACO1 Fusion FISH Probe
The UBE2R2-ACO1 Fusion FISH Probe is used to confirm a fusion of the UBE2R2 and ACO1 genes. The fusion of the UBE2R2 and ACO1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2R2-ACO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2R2-ACO1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACO1 Gene Summary
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
Gene Name: Aconitase 1
Chromosome: CHR9: 32384600 -32450832
Locus: 9p21.1
UBE2R2 Gene Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 R2
Chromosome: CHR9: 33817181 -33920401
Locus: 9p13.3
Gene Diseases
The UBE2R2 ACO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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