UBE2K-LIAS Fusion FISH Probe
The UBE2K-LIAS Fusion FISH Probe is used to confirm a fusion of the UBE2K and LIAS genes. The fusion of the UBE2K and LIAS genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2K-LIAS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2K-LIAS-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2K Gene Summary
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 K
Chromosome: CHR4: 39699663 -39784410
Locus: 4p14
LIAS Gene Summary
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Lipoic Acid Synthetase
Chromosome: CHR4: 39460664 -39479271
Locus: 4p14
Gene Diseases
The UBE2K LIAS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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