UBE2H-ZC3HC1 Fusion FISH Probe
The UBE2H-ZC3HC1 Fusion FISH Probe is used to confirm a fusion of the UBE2H and ZC3HC1 genes. The fusion of the UBE2H and ZC3HC1 genes has been associated with Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2H-ZC3HC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2H-ZC3HC1-20-AQAQ | 20 (40 μL) | 200 μL |
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UBE2H Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Gene Name: Ubiquitin Conjugating Enzyme E2 H
Chromosome: CHR7: 129470572 -129592800
Locus: 7q32.2
ZC3HC1 Gene Summary
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Gene Name: Zinc Finger C3HC-type Containing 1
Chromosome: CHR7: 129658125 -129691233
Locus: 7q32.2
Gene Diseases
The UBE2H ZC3HC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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