UBE2G2-SON Fusion FISH Probe
The UBE2G2-SON Fusion FISH Probe is used to confirm a fusion of the UBE2G2 and SON genes. The fusion of the UBE2G2 and SON genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2G2-SON-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2G2-SON-20-AQAQ | 20 (40 μL) | 200 μL |
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SON Gene Summary
This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: SON DNA Binding Protein
Chromosome: CHR21: 34915349 -34949812
Locus: 21q22.11
UBE2G2 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Ubiquitin Conjugating Enzyme E2 G2
Chromosome: CHR21: 46188494 -46221751
Locus: 21q22.3
Gene Diseases
The UBE2G2 SON Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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