UBE2E3-TECPR2 Fusion FISH Probe
The UBE2E3-TECPR2 Fusion FISH Probe is used to confirm a fusion of the UBE2E3 and TECPR2 genes. The fusion of the UBE2E3 and TECPR2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBE2E3-TECPR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-RERE | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-REOR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-REGO | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-REGR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-REAQ | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-ORRE | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-OROR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-ORGO | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GORE | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GOOR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GOGO | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GOGR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GRRE | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GROR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GRGO | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GRGR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-AQRE | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-AQOR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-AQGO | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-AQGR | 20 (40 μL) | 200 μL |
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| UBE2E3-TECPR2-20-AQAQ | 20 (40 μL) | 200 μL |
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TECPR2 Gene Summary
The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Tectonin Beta-propeller Repeat Containing 2
Chromosome: CHR14: 102829299 -102968818
Locus: 14q32.31
UBE2E3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 E3
Chromosome: CHR2: 181845111 -181928150
Locus: 2q31.3
Gene Diseases
The UBE2E3 TECPR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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