UBE2D2-ARHGAP26 Fusion FISH Probe
The UBE2D2-ARHGAP26 Fusion FISH Probe is used to confirm a fusion of the UBE2D2 and ARHGAP26 genes. The fusion of the UBE2D2 and ARHGAP26 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBE2D2-ARHGAP26-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-RERE | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-REOR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-REGO | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-REGR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-OROR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GORE | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GROR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| UBE2D2-ARHGAP26-20-AQAQ | 20 (40 μL) | 200 μL |
|
UBE2D2 Gene Summary
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: Ubiquitin Conjugating Enzyme E2 D2
Chromosome: CHR5: 138940750 -139008018
Locus: 5q31.2
ARHGAP26 Gene Summary
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Gene Name: Rho GTPase Activating Protein 26
Chromosome: CHR5: 142150291 -142608572
Locus: 5q31.3
Gene Diseases
The UBE2D2 ARHGAP26 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|