UBASH3B-GRIK4 Fusion FISH Probe
The UBASH3B-GRIK4 Fusion FISH Probe is used to confirm a fusion of the UBASH3B and GRIK4 genes. The fusion of the UBASH3B and GRIK4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBASH3B-GRIK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-RERE | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-REOR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-REGO | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-REGR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-REAQ | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-ORRE | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-OROR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-ORGO | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GORE | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GOOR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GOGO | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GOGR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GRRE | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GROR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GRGO | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GRGR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-AQRE | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-AQOR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-AQGO | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-AQGR | 20 (40 μL) | 200 μL |
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| UBASH3B-GRIK4-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIK4 Gene Summary
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Glutamate Ionotropic Receptor Kainate Type Subunit 4
Chromosome: CHR11: 120531027 -120856969
Locus: 11q23.3
UBASH3B Gene Summary
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Associated And SH3 Domain Containing B
Chromosome: CHR11: 122526397 -122685187
Locus: 11q24.1
Gene Diseases
The UBASH3B GRIK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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