UBAP1-UNC13B Fusion FISH Probe
The UBAP1-UNC13B Fusion FISH Probe is used to confirm a fusion of the UBAP1 and UNC13B genes. The fusion of the UBAP1 and UNC13B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBAP1-UNC13B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-RERE | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-REOR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-REGO | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-REGR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-REAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-ORRE | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-OROR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-ORGO | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GORE | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GOOR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GOGO | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GOGR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GRRE | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GROR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GRGO | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GRGR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-AQRE | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-AQOR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-AQGO | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-AQGR | 20 (40 μL) | 200 μL |
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| UBAP1-UNC13B-20-AQAQ | 20 (40 μL) | 200 μL |
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UNC13B Gene Summary
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Gene Name: Unc-13 Homolog B
Chromosome: CHR9: 35161988 -35405332
Locus: 9p13.3
UBAP1 Gene Summary
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Name: Ubiquitin Associated Protein 1
Chromosome: CHR9: 34179002 -34252521
Locus: 9p13.3
Gene Diseases
The UBAP1 UNC13B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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