UBAP1-UBE2R2 Fusion FISH Probe
The UBAP1-UBE2R2 Fusion FISH Probe is used to confirm a fusion of the UBAP1 and UBE2R2 genes. The fusion of the UBAP1 and UBE2R2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBAP1-UBE2R2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-RERE | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-REOR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-REGO | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-REGR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-REAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-ORRE | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-OROR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-ORGO | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GORE | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GOOR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GOGO | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GOGR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GRRE | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GROR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GRGO | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GRGR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-AQRE | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-AQOR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-AQGO | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-AQGR | 20 (40 μL) | 200 μL |
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| UBAP1-UBE2R2-20-AQAQ | 20 (40 μL) | 200 μL |
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UBAP1 Gene Summary
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Name: Ubiquitin Associated Protein 1
Chromosome: CHR9: 34179002 -34252521
Locus: 9p13.3
UBE2R2 Gene Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Conjugating Enzyme E2 R2
Chromosome: CHR9: 33817181 -33920401
Locus: 9p13.3
Gene Diseases
The UBAP1 UBE2R2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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