UBA3-FRMD4B Fusion FISH Probe
The UBA3-FRMD4B Fusion FISH Probe is used to confirm a fusion of the UBA3 and FRMD4B genes. The fusion of the UBA3 and FRMD4B genes has been associated with Uterine Corpus Endometrial Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UBA3-FRMD4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-RERE | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-REOR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-REGO | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-REGR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-REAQ | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-ORRE | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-OROR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-ORGO | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GORE | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GOOR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GOGO | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GOGR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GRRE | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GROR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GRGO | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GRGR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-AQRE | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-AQOR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-AQGO | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-AQGR | 20 (40 μL) | 200 μL |
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| UBA3-FRMD4B-20-AQAQ | 20 (40 μL) | 200 μL |
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UBA3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Like Modifier Activating Enzyme 3
Chromosome: CHR3: 69103880 -69129524
Locus: 3p14.1
FRMD4B Gene Summary
This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]
Gene Name: FERM Domain Containing 4B
Chromosome: CHR3: 69219145 -69435430
Locus: 3p14.1
Gene Diseases
The UBA3 FRMD4B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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