UACA-LTK Fusion FISH Probe
The UACA-LTK Fusion FISH Probe is used to confirm a fusion of the UACA and LTK genes. The fusion of the UACA and LTK genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UACA-LTK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-RERE | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-REOR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-REGO | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-REGR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-REAQ | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-ORRE | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-OROR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-ORGO | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-ORAQ | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GORE | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GOOR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GOGO | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GOGR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GOAQ | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GRRE | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GROR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GRGO | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GRGR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-GRAQ | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-AQRE | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-AQOR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-AQGO | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-AQGR | 20 (40 μL) | 200 μL |
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| UACA-LTK-20-AQAQ | 20 (40 μL) | 200 μL |
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LTK Gene Summary
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Leukocyte Receptor Tyrosine Kinase
Chromosome: CHR15: 41795839 -41806085
Locus: 15q15.1
UACA Gene Summary
This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]
Gene Name: Uveal Autoantigen With Coiled-coil Domains And Ankyrin Repeats
Chromosome: CHR15: 70946892 -71055850
Locus: 15q23
Gene Diseases
The UACA LTK Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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