TYR-MMP20 Fusion FISH Probe
The TYR-MMP20 Fusion FISH Probe is used to confirm a fusion of the TYR and MMP20 genes. The fusion of the TYR and MMP20 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TYR-MMP20-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-RERE | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-REOR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-REGO | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-REGR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-REAQ | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-ORRE | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-OROR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-ORGO | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-ORAQ | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GORE | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GOOR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GOGO | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GOGR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GOAQ | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GRRE | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GROR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GRGO | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GRGR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-GRAQ | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-AQRE | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-AQOR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-AQGO | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-AQGR | 20 (40 μL) | 200 μL |
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| TYR-MMP20-20-AQAQ | 20 (40 μL) | 200 μL |
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TYR Gene Summary
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
Gene Name: Tyrosinase
Chromosome: CHR11: 88911039 -89028927
Locus: 11q14.3
MMP20 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
Gene Name: Matrix Metallopeptidase 20
Chromosome: CHR11: 102447565 -102496063
Locus: 11q22.2
Gene Diseases
The TYR MMP20 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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