TYMS-YES1 Fusion FISH Probe
The TYMS-YES1 Fusion FISH Probe is used to confirm a fusion of the TYMS and YES1 genes. The fusion of the TYMS and YES1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TYMS-YES1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| TYMS-YES1-20-AQAQ | 20 (40 μL) | 200 μL |
|
TYMS Gene Summary
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Gene Name: Thymidylate Synthetase
Chromosome: CHR18: 657603 -673499
Locus: 18p11.32
YES1 Gene Summary
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Gene Name: YES Proto-oncogene 1, Src Family Tyrosine Kinase
Chromosome: CHR18: 721591 -812327
Locus: 18p11.32
Gene Diseases
The TYMS YES1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|