TXNRD2-RTN4R Fusion FISH Probe
The TXNRD2-RTN4R Fusion FISH Probe is used to confirm a fusion of the TXNRD2 and RTN4R genes. The fusion of the TXNRD2 and RTN4R genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TXNRD2-RTN4R-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-RERE | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-REOR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-REGO | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-REGR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-REAQ | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-ORRE | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-OROR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-ORGO | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-ORAQ | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GORE | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GOOR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GOGO | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GOGR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GOAQ | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GRRE | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GROR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GRGO | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GRGR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-GRAQ | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-AQRE | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-AQOR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-AQGO | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-AQGR | 20 (40 μL) | 200 μL |
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| TXNRD2-RTN4R-20-AQAQ | 20 (40 μL) | 200 μL |
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TXNRD2 Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Thioredoxin Reductase 2
Chromosome: CHR22: 19863039 -19929359
Locus: 22q11.21
RTN4R Gene Summary
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Gene Name: Reticulon 4 Receptor
Chromosome: CHR22: 20228937 -20255816
Locus: 22q11.21
Gene Diseases
The TXNRD2 RTN4R Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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