TXNRD1-HCFC2 Fusion FISH Probe
The TXNRD1-HCFC2 Fusion FISH Probe is used to confirm a fusion of the TXNRD1 and HCFC2 genes. The fusion of the TXNRD1 and HCFC2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TXNRD1-HCFC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-RERE | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-REOR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-REGO | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-REGR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-REAQ | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-ORRE | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-OROR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-ORGO | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GORE | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GOOR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GOGO | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GOGR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GRRE | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GROR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GRGO | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GRGR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-AQRE | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-AQOR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-AQGO | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-AQGR | 20 (40 μL) | 200 μL |
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| TXNRD1-HCFC2-20-AQAQ | 20 (40 μL) | 200 μL |
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TXNRD1 Gene Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
Gene Name: Thioredoxin Reductase 1
Chromosome: CHR12: 104609558 -104744062
Locus: 12q23.3
HCFC2 Gene Summary
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
Gene Name: Host Cell Factor C2
Chromosome: CHR12: 104458235 -104500304
Locus: 12q23.3
Gene Diseases
The TXNRD1 HCFC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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