TXNDC5-RREB1 Fusion FISH Probe
The TXNDC5-RREB1 Fusion FISH Probe is used to confirm a fusion of the TXNDC5 and RREB1 genes. The fusion of the TXNDC5 and RREB1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TXNDC5-RREB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-RERE | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-REOR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-REGO | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-REGR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-REAQ | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-ORRE | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-OROR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-ORGO | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GORE | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GOOR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GOGO | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GOGR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GRRE | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GROR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GRGO | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GRGR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-AQRE | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-AQOR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-AQGO | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-AQGR | 20 (40 μL) | 200 μL |
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| TXNDC5-RREB1-20-AQAQ | 20 (40 μL) | 200 μL |
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RREB1 Gene Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Name: Ras Responsive Element Binding Protein 1
Chromosome: CHR6: 7107829 -7252213
Locus: 6p24.3
TXNDC5 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
Gene Name: Thioredoxin Domain Containing 5
Chromosome: CHR6: 7881482 -7911047
Locus: 6p24.3
Gene Diseases
The TXNDC5 RREB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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