TUBD1-INPP5D Fusion FISH Probe
The TUBD1-INPP5D Fusion FISH Probe is used to confirm a fusion of the TUBD1 and INPP5D genes. The fusion of the TUBD1 and INPP5D genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TUBD1-INPP5D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-RERE | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-REOR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-REGO | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-REGR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-REAQ | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-ORRE | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-OROR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-ORGO | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-ORAQ | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GORE | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GOOR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GOGO | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GOGR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GOAQ | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GRRE | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GROR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GRGO | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GRGR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-GRAQ | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-AQRE | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-AQOR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-AQGO | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-AQGR | 20 (40 μL) | 200 μL |
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| TUBD1-INPP5D-20-AQAQ | 20 (40 μL) | 200 μL |
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INPP5D Gene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: Inositol Polyphosphate-5-phosphatase D
Chromosome: CHR2: 233925035 -234116549
Locus: 2q37.1
TUBD1 Gene Summary
The Tubulin Delta 1 (TUBD1) gene is located on chr17 :57936840-57970306 at 17q23.1.
Gene Name: Tubulin Delta 1
Chromosome: CHR17: 57936840 -57970306
Locus: 17q23.1
Gene Diseases
The TUBD1 INPP5D Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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