TUBB3-TRPM5 Fusion FISH Probe
The TUBB3-TRPM5 Fusion FISH Probe is used to confirm a fusion of the TUBB3 and TRPM5 genes. The fusion of the TUBB3 and TRPM5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TUBB3-TRPM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-RERE | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-REOR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-REGO | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-REGR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-REAQ | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-ORRE | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-OROR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-ORGO | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-ORAQ | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GORE | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GOOR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GOGO | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GOGR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GOAQ | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GRRE | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GROR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GRGO | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GRGR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-GRAQ | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-AQRE | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-AQOR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-AQGO | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-AQGR | 20 (40 μL) | 200 μL |
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| TUBB3-TRPM5-20-AQAQ | 20 (40 μL) | 200 μL |
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TUBB3 Gene Summary
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Gene Name: Tubulin Beta 3 Class III
Chromosome: CHR16: 89988416 -90002505
Locus: 16q24.3
TRPM5 Gene Summary
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]
Gene Name: Transient Receptor Potential Cation Channel Subfamily M Member 5
Chromosome: CHR11: 2425745 -2444275
Locus: 11p15.5
Gene Diseases
The TUBB3 TRPM5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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