TTR-ARFGEF2 Fusion FISH Probe
The TTR-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the TTR and ARFGEF2 genes. The fusion of the TTR and ARFGEF2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTR-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| TTR-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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TTR Gene Summary
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]
Gene Name: Transthyretin
Chromosome: CHR18: 29171729 -29178986
Locus: 18q12.1
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The TTR ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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