TTLL5-RGS6 Fusion FISH Probe
The TTLL5-RGS6 Fusion FISH Probe is used to confirm a fusion of the TTLL5 and RGS6 genes. The fusion of the TTLL5 and RGS6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTLL5-RGS6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-RERE | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-REOR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-REGO | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-REGR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-REAQ | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-ORRE | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-OROR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-ORGO | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GORE | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GOOR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GOGO | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GOGR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GRRE | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GROR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GRGO | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GRGR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-AQRE | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-AQOR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-AQGO | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-AQGR | 20 (40 μL) | 200 μL |
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| TTLL5-RGS6-20-AQAQ | 20 (40 μL) | 200 μL |
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RGS6 Gene Summary
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Gene Name: Regulator Of G Protein Signaling 6
Chromosome: CHR14: 72398816 -73033238
Locus: 14q24.2
TTLL5 Gene Summary
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
Gene Name: Tubulin Tyrosine Ligase Like 5
Chromosome: CHR14: 76127550 -76421425
Locus: 14q24.3
Gene Diseases
The TTLL5 RGS6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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