TTK-TMEM63B Fusion FISH Probe
The TTK-TMEM63B Fusion FISH Probe is used to confirm a fusion of the TTK and TMEM63B genes. The fusion of the TTK and TMEM63B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTK-TMEM63B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-RERE | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-REOR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-REGO | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-REGR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-REAQ | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-ORRE | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-OROR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-ORGO | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GORE | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GOOR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GOGO | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GOGR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GRRE | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GROR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GRGO | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GRGR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-AQRE | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-AQOR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-AQGO | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-AQGR | 20 (40 μL) | 200 μL |
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| TTK-TMEM63B-20-AQAQ | 20 (40 μL) | 200 μL |
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TTK Gene Summary
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Gene Name: TTK Protein Kinase
Chromosome: CHR6: 80714321 -80752244
Locus: 6q14.1
TMEM63B Gene Summary
The Transmembrane Protein 63B (TMEM63B) gene is located on chr6 :44095375-44123256 at 6p21.1.
Gene Name: Transmembrane Protein 63B
Chromosome: CHR6: 44095375 -44123256
Locus: 6p21.1
Gene Diseases
The TTK TMEM63B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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