TTC3-CBS Fusion FISH Probe
The TTC3-CBS Fusion FISH Probe is used to confirm a fusion of the TTC3 and CBS genes. The fusion of the TTC3 and CBS genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTC3-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| TTC3-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
TTC3 Gene Summary
The Tetratricopeptide Repeat Domain 3 (TTC3) gene is located on chr21 :38445570-38575408 at 21q22.13.
Gene Name: Tetratricopeptide Repeat Domain 3
Chromosome: CHR21: 38445570 -38575408
Locus: 21q22.13
Gene Diseases
The TTC3 CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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