TTC3-BRWD1 Fusion FISH Probe
The TTC3-BRWD1 Fusion FISH Probe is used to confirm a fusion of the TTC3 and BRWD1 genes. The fusion of the TTC3 and BRWD1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTC3-BRWD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-RERE | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-REOR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-REGO | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-REGR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-REAQ | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-ORRE | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-OROR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-ORGO | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GORE | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GOOR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GOGO | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GOGR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GRRE | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GROR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GRGO | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GRGR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-AQRE | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-AQOR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-AQGO | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-AQGR | 20 (40 μL) | 200 μL |
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| TTC3-BRWD1-20-AQAQ | 20 (40 μL) | 200 μL |
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TTC3 Gene Summary
The Tetratricopeptide Repeat Domain 3 (TTC3) gene is located on chr21 :38445570-38575408 at 21q22.13.
Gene Name: Tetratricopeptide Repeat Domain 3
Chromosome: CHR21: 38445570 -38575408
Locus: 21q22.13
BRWD1 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Gene Name: Bromodomain And WD Repeat Domain Containing 1
Chromosome: CHR21: 40557403 -40685712
Locus: 21q22.2
Gene Diseases
The TTC3 BRWD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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