TTC28-EWSR1 Fusion FISH Probe
The TTC28-EWSR1 Fusion FISH Probe is used to confirm a fusion of the TTC28 and EWSR1 genes. The fusion of the TTC28 and EWSR1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTC28-EWSR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-RERE | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-REOR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-REGO | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-REGR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-REAQ | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-ORRE | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-OROR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-ORGO | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GORE | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GOOR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GOGO | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GOGR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GRRE | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GROR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GRGO | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GRGR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-AQRE | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-AQOR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-AQGO | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-AQGR | 20 (40 μL) | 200 μL |
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| TTC28-EWSR1-20-AQAQ | 20 (40 μL) | 200 μL |
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EWSR1 Gene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Gene Name: EWS RNA Binding Protein 1
Chromosome: CHR22: 29663997 -29696515
Locus: 22q12.2
TTC28 Gene Summary
The Tetratricopeptide Repeat Domain 28 (TTC28) gene is located on chr22 :28374001-29075853 at 22q12.1.
Gene Name: Tetratricopeptide Repeat Domain 28
Chromosome: CHR22: 28374001 -29075853
Locus: 22q12.1
Gene Diseases
The TTC28 EWSR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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