TTC19-MMP28 Fusion FISH Probe
The TTC19-MMP28 Fusion FISH Probe is used to confirm a fusion of the TTC19 and MMP28 genes. The fusion of the TTC19 and MMP28 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TTC19-MMP28-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-RERE | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-REOR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-REGO | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-REGR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-REAQ | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-ORRE | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-OROR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-ORGO | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-ORAQ | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GORE | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GOOR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GOGO | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GOGR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GOAQ | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GRRE | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GROR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GRGO | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GRGR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-GRAQ | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-AQRE | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-AQOR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-AQGO | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-AQGR | 20 (40 μL) | 200 μL |
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| TTC19-MMP28-20-AQAQ | 20 (40 μL) | 200 μL |
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TTC19 Gene Summary
This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2012]
Gene Name: Tetratricopeptide Repeat Domain 19
Chromosome: CHR17: 15902693 -15932723
Locus: 17p12
MMP28 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Name: Matrix Metallopeptidase 28
Chromosome: CHR17: 34092875 -34122640
Locus: 17q12
Gene Diseases
The TTC19 MMP28 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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