TSPAN8-UTRN Fusion FISH Probe
The TSPAN8-UTRN Fusion FISH Probe is used to confirm a fusion of the TSPAN8 and UTRN genes. The fusion of the TSPAN8 and UTRN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TSPAN8-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| TSPAN8-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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TSPAN8 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tetraspanin 8
Chromosome: CHR12: 71518876 -71551779
Locus: 12q21.1
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The TSPAN8 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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